The most common arrhythmias and heart block<\/strong> are found in case of poisoning with cardiac glycosides, beta-blockers, calcium ATP-ase blockers, quinidine preparations, clonidine, chemomerine, BACKGROUND.<\/p>\n The pathogenesis of rhythm and conduction<\/strong> disorders is caused by impaired neurohumoral regulation of the heart, changes in the permeability of cell membranes for potassium, sodium and calcium ions, inhibition of the KN pump, a decrease in the ATP-az activity of the plasma membrane of the cardiomyocyte sarcolemma. Suppressed active transport of sodium ions from the cell and potassium ions into the cell. There is a blockade of tissue enzymes, activation of lipid peroxidation appears, acidosis and tissue hypoxia join.<\/p>\n Some cardiotropic drugs have their own pathogenesis features.<\/p>\n Clinical picture.<\/strong> Cardiotropic poisoning causes the development of bradyarrhythmias. The first signs of a primary cardiotoxic effect are often acute bradycardia (20\u201340 per minute), an increase in electrical heart systole (QT interval) and a systolic index (SP). In severe poisoning, nodal or idioventricular rhythms, shinoauricular, atrioventricular, and intra-ventricular blockade are noted.<\/p>\n On ECG in patients with helmer poisoning, sinus bradycardia is noted (30-60 per minute) without complex rhythm and conduction disturbances.<\/p>\n Cardiac glycosides can cause complex heart rhythm and conduction disorders: ventricular extrasystole, sinoauricular and atrioventricular block, ventricular fibrillation, cardiac arrest.<\/p>\n Verapamil poisoning gives the most severe and complex arrhythmias. Often there is a failure in the sinus node, the transition of the pacemaker in the atrioventricular node or the ventricular conduction system. Often, death occurs from ventricular asystole.<\/p>\n Beta-adrenergic blocking poisoning causes the same rhythm and conduction disturbances as verapamil poisoning.<\/p>\n Patients with tricyclic antidepressant poisoning (amitriptyline) can have either severe tachycardia or severe bradycardia with an intra-ventricular blockade (QRS = 0.12-0.18 s). In severe poisoning, death occurs from ventricular fibrillation.<\/p>\n Treatment of arrhythmias and heart block<\/strong> with appropriate drugs is effective only against the background of antidote therapy, natural and surgical methods of detoxification.<\/p>\n","protected":false},"excerpt":{"rendered":" What are Arrhythmias and Heart Block in Cardiotropic Poisoning? The most common arrhythmias and heart block are found in case of poisoning with cardiac glycosides, beta-blockers, calcium ATP-ase blockers, quinidine preparations, clonidine, chemomerine, BACKGROUND. Pathogenesis<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/pain-relief-med.com\/blog\/wp-json\/wp\/v2\/posts\/23"}],"collection":[{"href":"https:\/\/pain-relief-med.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pain-relief-med.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pain-relief-med.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pain-relief-med.com\/blog\/wp-json\/wp\/v2\/comments?post=23"}],"version-history":[{"count":1,"href":"https:\/\/pain-relief-med.com\/blog\/wp-json\/wp\/v2\/posts\/23\/revisions"}],"predecessor-version":[{"id":24,"href":"https:\/\/pain-relief-med.com\/blog\/wp-json\/wp\/v2\/posts\/23\/revisions\/24"}],"wp:attachment":[{"href":"https:\/\/pain-relief-med.com\/blog\/wp-json\/wp\/v2\/media?parent=23"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pain-relief-med.com\/blog\/wp-json\/wp\/v2\/categories?post=23"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pain-relief-med.com\/blog\/wp-json\/wp\/v2\/tags?post=23"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Pathogenesis during Arrhythmias and Heart Block in Cardiotropic Poisoning<\/h2>\n
Symptoms of Arrhythmias and Heart Block in Cardiotropic Poisoning<\/h2>\n
Treatment of Arrhythmias and Heart Block in Cardiotropic Poisonings<\/h2>\n